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Mahesh

29/10/22 22:31 PM IST

Homegrown CAR-T cells 'cure' 8-year-old's leukemia

In News 
  • The eight-year-old got the treatment as part of the safety trials for India’s first indigenously made CAR-T cells — a joint effort between IIT-Bombay and Tata Memorial Centre, Mumbai.
CAR-T cells therapy 
  • It is a type of treatment in which a patient’s T cells (a type of immune cell) are changed in the laboratory so they will bind to cancer cells and kill them.
  • CAR-T cells are a new form of, immunotherapy, itself a fledgling branch of cancer treatment.
  • It entails re-engineering the body’s T immune cells with some genetic material so that they selectively target cancer cells for destruction.
  • In this therapy, Blood from a vein in the patient’s arm flows through a tube to an apheresis machine (not shown), which removes the white blood cells, including the T cells, and sends the rest of the blood back to the patient.
  • Then, the gene for a special receptor called a chimeric antigen receptor (CAR) is inserted into the T cells in the laboratory.
  • Millions of CAR T cells are grown in the laboratory and then given to the patient by infusion. The CAR T cells are able to bind to an antigen on the cancer cells and kill them.
Source- Times of India 

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