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Health & Medicine
Pradeep Kumar

25/02/21 09:30 AM IST

Potential drug candidate for the treatment of Alzheimer’s

In news

Scientists have developed a small molecule that disrupts the mechanism through which neurons become dysfunctional in Alzheimer’s disease (AD)
The novel drug candidate TGR63 developed by the JNCASR team has potential as a promising drug candidate for AD treatment.  

Alzheimer’s disease
  • In the Alzheimer's brain, abnormal levels of naturally forming protein clump together to form plaques that collect between neurons and disrupt cell function.
  • This is caused by production and deposition of the amyloid peptide (Aβ) that accumulates  in the central nervous system.
  • The multifactorial nature of Alzheimer’s disease (AD) attributed to multifaceted amyloid toxicity has kept researchers from developing effective treatment
  • AD severely affects the patients, families, caregivers and hence is a major societal and economic burden globally.
About the study
  • The detailed studies established the molecule called TGR63 as the lead candidate to rescue neuronal cells from amyloid toxicity.
  • The molecule was also found to reduced amyloid burden in the cortex and hippocampus, or a complex part embedded deep into the temporal lobe, thereby reversing cognitive decline.
  • This research has been published recently in the journalAdvanced Therapeutics.
Source: PIB

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