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Science & Tech.
Pradeep Kumar

18/07/21 11:25 AM IST

Tool to study cancer-causing mutations

In news

Researchers at IIT Madras have developed an AI tool called NBDriver (neighbourhood driver) for use in analysing cancercausing mutations in cells.

Details
  • By looking at the neighbourhood, or context, of a mutation in the genome, it can look at harmful “driver” mutations and distinguish them from neutral “passenger” mutations.
  • This technique of looking at the genomic neighbourhood to make out the nature of the mutation is a novel and largely unexplored one.
  • The method of distinguishing between driver and passenger mutations solely by looking at the neighbourhood is novel.  
Way forward
  • For the future, the group aims to develop an easy-to-use drag-and-drop web interface that will enable cancer researchers with limited computational or programming skills to get predictions and extract genomic information on their preferred set of mutations.
  • The group also plans that NBDriver will be a part of a broader cancer genomic sequence analysis "pipeline" being developed at the centres.
Source: The Hindu

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